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Sixty seconds on . . . fasting

51app 2024; 384 doi: (Published 02 February 2024) Cite this as: 51app 2024;384:q278

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Re: Sixty seconds on . . . fasting

Dear Editor
Dear Sir ,We have read your nice article by Anne Gulland (51app 2024; 384 doi: (Published 02 February 2024)Cite this as: 51app 2024;384:q278) . Intermittent and periodic fasting are free from side effects and are emerging as safe means to increase longevity and healthspan by acting on cellular aging and disease risk factors (1), Before doing fasting the individual should be taking a balanced diet ,rich in plant based foods and should consume sufficient water. Fasting may be helpful for people with diabetes in improving insulin sensitivity and glucose control (2). People taking antihypertensives should monitor their blood pressure and heart rate during fasting. People with diabetes mellitus should take adequate protein when they are fasting ,it may be necessary to take vitamin and/or mineral supplements also.
The gut microbiota impairment is also associated with cardiovascular disease, neurodegeneration, nonalcoholic fatty liver disease, colon cancer, etc. Fasting or caloric restriction may change the gut environment by changing the nutrient availability and energy sources, which can influence the growth of certain microbial organisms and influence short chain fatty acids production.(3).Intermittent fasting influences the brain and cognitive function , this will potentially reverse or delay the pathological process in Alzheimer’s disease (4). Drinking water may be an important factor in shaping the human gut microbiome and also it is a macronutrient(5).
References :
1. Longo VD, Di Tano M, Mattson MP, Guidi N. Intermittent and periodic fasting, longevity and disease. Nat Aging. 2021 Jan;1(1):47-59. doi: 10.1038/s43587-020-00013-3. Epub 2021 Jan 14. PMID: 35310455
2. Purdel C, Margină D, Adam-Dima I, Ungurianu A. The Beneficial Effects of Dietary Interventions on Gut Microbiota-An Up-to-Date Critical Review and Future Perspectives. Nutrients. 2023 Dec 3;15(23):5005.
3. Fortinguerra F., Ambrosino F., Pierantozzi A., DaCas R., Trotta F., Cangini A. L’uso degli antibiotici in Italia. Il rapporto nazionale. OsMed 2019. Agenzia Italiana del Farmaco; Roma, Italy: 2021.
4. Elias A, Padinjakara N, Lautenschlager NT. Effects of intermittent fasting on cognitive health and Alzheimer's disease. Nutr Rev. 2023 Aug 10;81(9):1225-1233.
5. Vanhaecke T, Bretin O, Poirel M, Tap J. Drinking Water Source and Intake Are Associated with Distinct Gut Microbiota Signatures in US and UK Populations. J Nutr. 2022 Jan 11;152(1):171-182. doi: 10.1093/jn/nxab312. PMID: 34642755;

Dr mahantayya V Math, Honorary Associate Professor in Physiology, MGM Medical college , Navi Mumbai, India
Dr Suraj M Math., Senior Clinical Fellow,, General Surgery, WWL,NHS Trust UK

Competing interests: No competing interests

19 February 2024
Mahantayya V. Math
Honorary associate professor in physiology
Dr Suraj M Math, Senior Clinical Fellow,, General Surgery, WWL,NHS Trust UK
MGM Medical College, Navi Mumbai, India
Rh II, R-17, Lane ! , Sector 9 , CBD Belapur , Navi Mumbai , Maharashtra State, India